Head of Computational Chemistry


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Lexicon Pharmaceuticals has an exciting opportunity for a head of Computational Chemistry in the Hopewell, N.J. area.

Lexicon is a biopharmaceutical company focused on the discovery of breakthrough treatments for human disease. To generate our discoveries, we use our patented gene targeting and gene trapping technologies to alter the DNA of specific genes in mouse embryonic stem cells. These unique cells are cloned to create in vivo mammalian models of drug target function enabling the discovery of pharmaceutically valuable proteins and drug targets. These gene function discoveries fuel our drug discovery programs in cardiology, diabetes, oncology, immunology and neurology. Our industrialized biology function operates out of our Woodlands, Texas campus.

Our medicinal chemistry technology is housed in a state-of-the-art 76,000 square foot facility in Hopewell, New Jersey, which is located in close proximity to many major pharmaceutical companies. Our lead optimization chemistry groups are organized around specific discovery targets and work closely with their pharmaceutical biology counterparts in our facilities in The Woodlands, Texas. The medicinal chemists optimize lead compounds in order to select clinical candidates with the desired absorption, distribution, metabolism, excretion and physicochemical characteristics. We have the capability to profile our compounds using the same battery of in vivo assays that we use to characterize our drug discovery targets. This provides us with valuable detailed information relevant to the selection of the highest quality compounds for clinical development. We are currently recruiting for a proven computational chemist to build a cutting edge modeling and computational chemistry effort to support the drug discovery efforts of a department of approximately 50 chemists at Lexicon Pharmaceuticals in Princeton, NJ. In addition to expertise in modeling and computational technologies, the successful candidate will have the capacity to work independently within a highly focused team environment and demonstrate leadership, creativity and adaptability in their scientific work. This position requires a high degree of focus on scientific results, innovation, and team spirit coupled with strong organizational skills. Job objectives include the definition and acquisition of appropriate modeling software to support medicinal chemistry, the creation of pharmacophore, homology, QSAR and other empirical models and scientific interaction with experienced medicinal chemistry teams to generate structural hypotheses from project data. Several projects will also require accessing and manipulating crystallographic data, ligand docking to active sites and homology modeling.

Qualified candidates must possess the following:

bullet Ph.D. in Chemistry 
bullet 5 years of experience in drug discovery working with medicinal chemistry teams in a multidisciplinary project environment and
bullet a demonstrated ability to provide scientific leadership on a day-to-day basis. 

As an employee of Lexicon, you will have the opportunity to make significant, personal contributions to the growth and development of the Company. In return, Lexicon is dedicated to providing its employees with opportunities for career development, exciting research assignments and a comprehensive benefits program that is part of a progressive compensation
package. Interested candidates may email a resume to: marym@lexgen.com.
Lexicon Genetics is an equal opportunity/affirmative action employer. 

Last updated: August 20, 2003

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