Senior CADD Scientist


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Our client, a well recognized leader in the pharmaceutical industry, currently has the following newly created position available in their "state-of-the-art" research facility located in the North East.


This hand-on role reporting to the Head, Structural Research will provide expertise in molecular modeling to enhance lead-optimization/identification for their multiple drug discovery programs.

DUTIES AND RESPONSIBILITIES include but are not limited to the following:

bullet Responsible for structure-based modeling (binding models, binding affinities, pharmacophore searches, de novo compound design), SAR analysis, and structure-guided library design in support of lead-optimization projects.
bullet Responsible for cheminformatic analyses of hit sets, structure-based modeling, SAR analysis, and structure-guided and/or cheminformatic-guided library design in support of lead-identification projects.
bullet Provide support to pre-screening projects through structure-based, target-class-based, and/or cheminformatic-based selection of compound screening sets.
bullet Provide new and innovative methodologies in computational biology to the design of optimum constructs for experimental structure determination efforts.
bullet Represent structural research group as a member of interdisciplinary project teams involved in target validation, lead identification and lead optimization.
bullet Maintain all appropriate notebook records for all studies assuring that normal lab SOP requirements are adhered to.

REQUIREMENTS: Ph.D. Computational Chemistry, Organic Chemistry or a related disciplines with pharmaceutical/biotechnology industry experience focused on computer-aided drug design (CADD) and demonstrable practical exposure to chemical informatics (cheminformatics). Experience working with a variety of CADD methodologies, e.g., structure-based compound design, prediction of compound binding affinities, prediction of compound ADME properties, compound-to-target docking, virtual screening (preferably high-throughput), and molecular library design are required. You must have excellent oral and written, communication and presentation skills. The ability to work in a fast-paced, goal-oriented team environment is needed. Leadership potential
is a strong plus. Familiarity with methodologies in computational biology a plus.

COMPENSATION: $95.0K - $120.0K base salary, bonus eligible, 401K, pension plan, excellent benefits plans, full relocation.

Please forward resume/CV in confidence to:
Dean Kaplan, Kaplan Scientific
(203) 406-2314, Fax (203) 406-2315, DEAN@KAPSCI.COM, WWW.KAPSCI.COM

Last updated: March 29, 2002

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