System Architect


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Specialized Supercomputer for Computational Drug Design

Extraordinarily gifted systems architects (including one senior technical manager) and ASIC/FPGA engineers are sought to participate in the development of a special-purpose supercomputer designed to fundamentally transform the process of drug discovery within the pharmaceutical industry.

This early-stage, rapidly growing project is being financed by the D. E. Shaw group, an investment and technology development firm with over $11 billion in aggregate capital. The project was initiated by the firm's founder, Dr. David E. Shaw, and operates under his direct scientific leadership.

This project aims to combine an innovative, massively parallel architecture incorporating application-specific integrated circuits and FPGAs with novel mathematical techniques and groundbreaking algorithmic advances in computational biochemistry to direct unprecedented computational power toward the solution of key scientific and technical problems in the field of molecular design. Successful candidates will be working closely with a number of the world's leading computational chemists and biologists, and will have the opportunity not only to participate in an exciting entrepreneurial venture with considerable economic potential, but to make fundamental contributions within the fields of biology, chemistry and medicine.

The candidates we seek will be unusually intelligent and accomplished, with a demonstrated ability to design and implement complex, high-performance hardware solutions based on ASIC and/or FPGA technologies. We are prepared to reward exceptionally well-qualified individuals with above-market compensation.

Contact: ilona [at]

The D. E. Shaw group members do not discriminate, in employment matters, on the basis of race, color, religion, gender, national origin, age, military service eligibility, veteran status, sexual orientation, marital status, disability, or any other protected class.

Last updated: April 6, 2005

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